Defending champion Pottsville relocated to Wilkes-Barre for the 1952-53 Eastern League season and became the Aces, but the new locale didn't work out and the team dropped four games into the season. The Sunbury Mercuries, last years runner-up, rolled off an 18-3 record and ran away with the regular season crown. Williamsport finished a distant second. The Berwick Car-Builders returned to the league after a year absence and slipped past Harrisburg for the final spot in the playoffs. The Harrisburg Senators, in what would be their only only year in the league, finished a half-game out of the playoffs. The new entry from Lebanon, Pennsylvania, the Seltzers, dropped their first 8 en route to a last-place finish.
In the playoffs, Berwick shocked Sunbury, beating them in 3 games in the semi-finals. Lancaster was unable to secure a home court for the playoffs, so their series with Williamsport was converted to a single game, which the Billies won. Williamsport dropped the opening game to Berwick in the best-of-three championship series before Williamsport won games 2 and 3 to win the title.
- Berwick Carbuilders
- Harrisburg Senators
- Lancaster Rockets
- Lebanon Seltzers
- Sunbury Mercuries
- Wilkes-Barre Aces
- Williamsport Billies
